Edit |   |
Antigenic Specificity | ZAP70 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human. predicted: mouse, rat. |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 100ug/100ul |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Immunogen | Immunogen: Rabbit polyclonal ZAP70 (1) antibody was raised against a recombinate human ZAP70 protein 71-303aa (BC039039). |
Other Names | [ZAP70 protein; Tyrosine-protein kinase ZAP-70; tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; syk-related tyrosine kinase; zeta-chain associated protein kinase, 70kD; zeta-chain (TCR) associated protein kinase 70kDa; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase], [ZAP70; ZAP70; SRK; STD; TZK; STCD; ZAP-70] |
Gene, Accession # | [ZAP70], Gene ID: 7535, NCBI: AAH39039.1 |
Catalog # | MBS416180 |
Price | $230 |
Order / More Info | ZAP70 Antibody from MYBIOSOURCE INC. |
Product Specific References | (1) Kremer,K.N., Kumar,A. and Hedin,K.E. G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions. J. Immunol. 187 (6), 3177-3185 (2011). |