RAS Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | RAS |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat, bovine |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 0.025 mg |
| Concentration | 1 mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Detects ~21kDa. The 21 kDa guanine-nucleotide binding proteins (K-Ras, H-Ras and N-Ras) cycle between active (GTPbound) and inactive (GDP-bound) forms (1). Receptor tyrosine kinases and G-protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway (2-4). GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway (5). The most common oncogenic Ras mutation found in tumors is Gly12 to Asp (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein (5,6). |
| Immunogen | Immunogen: Synthetic peptide corresponding to amino acids 31-43 of human RAS. (The immunogen peptide is from the effector binding loop (l2) of the H, K and N-Ras (AA31-43). This sequence is identical yeast, slime mould, fungi, Xenopus, rat, mouse and chicken over these residues.) Immunogen Species: Human |
| Other Names | [Rabbit Human RAS; GTPase Hras; GTPase Kras; GTPase Nras; Ha Ras; K Ras; K ras p21; KRAS; NRAS; p21ras; RASH1] |
| Gene, Accession # | [RAS], Gene ID: 18176, NCBI: NP_035067.2, UniProt: B2KGV5 |
| Catalog # | MBS8002014 |
| Price | $215 |
| Order / More Info | RAS Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Boguski M.S. and McCormick F. (1993) Nature 366: 643-654. 2. Avruch J., et al. (1994) Trends Biochem. Sci.19: 279-283. 3. Buday L. and Downward J. (1993) Cell 73: 611-620. 4. Huang D.C., et al. (1993) Mol. Cell Biol. 13: 2420-2431. 5. Bos J.L. (1989) Cancer Res. 49: 4682-4689. 6. Ma J. and Karplus M. (1997) J. Mol. Biol. 274:114-131. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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