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Antigenic Specificity | SCF |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two iso |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against an 18 amino acid peptide from near the center of human SCF. |
Other Names | [Stem cell factor, Mast cell growth factor, MGF, c-kit ligand, KL-1, KITLG, SHEP7] |
Gene, Accession # | [SCF], Gene ID: 4254, NCBI: NP_000890.1, UniProt: P21583 |
Catalog # | MBS9409548 |
Price | $320 |
Order / More Info | SCF Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |