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Antigenic Specificity | Human Cullin-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BT |
Immunogen | Immunogen: Recombinant human Cullin-1 protein(500-776aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8552 / sc-11384 |
Other Names | [CUL-1; CUL1], [CUL1; CUL1; CUL-1] |
Gene, Accession # | [CUL1], Gene ID: 8454, NCBI: NP_003583.2, UniProt: Q13616 |
Catalog # | MBS1493617 |
Price | $120, $160 |
Order / More Info | Human Cullin-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |