NCAM / CD56 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | NCAM / CD56 |
| Clone | polyclonal |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody 123A8 is directed against human NCAM/CD56 and reacts with an epitope within the membrane-proximal region of the NCAM molecule. The antibody binds to all NCAM isoforms. NCAM / CD56, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by post-translational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Th |
| Immunogen | Source Note: 123A8 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with cells from a mouse immunized with a membrane preparation of a human small cell lung carcinoma. |
| Other Names | n/a |
| Gene, Accession # | [NCAM / CD56] |
| Catalog # | MBS570443 |
| Price | $415 |
| Order / More Info | NCAM / CD56 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Moolenaar CE, Muller EJ, Schol DJ, Figdor CG, Bock E, Bitter-Suermann D, Michalides RJ.(1990). Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell lines H69 and CHP-212. Cancer Res. 50:1102-1106. 2. Langdon SP, Hawkes MM, Hay FG, Lawrie SS, Schol DJ, Hilgers J, Leonard RC, Smyth JF. (1988). Effect of sodium butyrate and other differentiation inducers on poorly differentiated human ovarian adenocarcinoma cell lines. Cancer Res. 48:6161- 6165. 3. Langdon SP, Lawrie SS, Hay FG, Hawkes MM, McDonald A, Hayward IP, Schol DJ, Hilgers J, Leonard RC, Smyth JF. (1988). Characterization and properties of nine human ovarian adenocarcinoma cell lines. Cancer Res. 48:6166-6172. 4. Gerardy-Schahn R, Eckhardt M. (1994). Hot spots of antigenicity in the neural cell adhesion molecule NCAM. Int J Cancer Suppl.8:38-42. 5. Kwa HB, Wesseling J, Verhoeven AH, van Zandwijk N, Hilkens J. (1996). Immunoscintigraphy of small-cell lung cancer xenografts with anti neural cell adhesion molecule monoclonal antibody, 123C3: improvement of tumour uptake by internalisation. Br J Cancer. 73:439-446. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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