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Antigenic Specificity | DPPA3 (C-term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL |
Concentration | vial concentration: 0.28 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This DPPA3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 145-179 amino acids from the C-terminal region of human DPPA3. Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects materna |
Immunogen | n/a |
Other Names | [Developmental pluripotency-associated protein 3; Stella-related protein; DPPA3; STELLAR] |
Gene, Accession # | [DPPA3], Gene ID: 359787, NCBI: NP_954980.1, UniProt: Q6W0C5 |
Catalog # | MBS9211508 |
Price | $150 |
Order / More Info | DPPA3 (C-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Payer B.,et al.Curr. Biol. 13:2110-2117(2003). Clark A.T.,et al.Stem Cells 22:169-179(2004). Julaton V.T.,et al.Hum. Mol. Genet. 20:2238-2250(2011). Bowles J.,et al.Cytogenet. Genome Res. 101:261-265(2003). |