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Antigenic Specificity | 4E-BP1 (Phospho Thr70) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Immunohistochemistry (IHC) Paraffin, ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-4E-BP1 (T70) Polyclonal Antibody detects endogenous levels of 4E-BP1 protein only when phosphorylated at T70. EIF4EBP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. |
Immunogen | Immunogen: Synthesized peptide derived from human 4E-BP1 around the phosphorylation site of T70 |
Other Names | [Rabbit 4E-BP1 (phospho Thr70); EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat-and acid-stable protein regulated by insulin 1; PHAS-I] |
Gene, Accession # | [4E-BP1], Gene ID: 1978, NCBI: NP_004086.1, UniProt: Q13541 |
Catalog # | MBS9704722 |
Price | $130, $220, $325 |
Order / More Info | 4E-BP1 (Phospho Thr70) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |