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Antigenic Specificity | DISC1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell |
Immunogen | Immunogen: Recombinant Human Disrupted in schizophrenia 1 protein (99-325AA) |
Other Names | [Disrupted in schizophrenia 1 protein; DISC1; KIAA0457] |
Gene, Accession # | [DISC1], Gene ID: 27185, NCBI: NP_001012975.1, UniProt: Q9NRI5 |
Catalog # | MBS7051489 |
Price | $160, $235 |
Order / More Info | DISC1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |