Description | Specificity: Murine CD28. CD28 is a type I disulfide-linked homodimer that is constitutively expressed on most thymocytes, at low density on nearly all CD4^+ and CD8^+ peripheral T lymphocytes, and at very low levels on NK cells. Its expression is upregulated upon T-cell activation.1-4 CD28 is a ligand for CD80/B7-1 and CD86/B7-2 on B cells and other antigen presenting cells, and plays an important role in the interaction between T cells and B cells.^5 CD28 is a co-stimulatory receptor involved in many, but not all, T-cell independent immune responses.^6-9. |
Product Specific References | 1. Gross, J.A., E. Callas, and J.P. Allison. 1992. J. Immunol. 149:380.2. Nandi, D., J.A. Gross, and J.P. Allison. 1994. J. Immunol. 152:3361.3. June, C.H., J.A. Ledbetter, P.S. Linsley, and C.B. Thompson. 1990. Immunol. Today 11:211.4. Giese, T., J.P. Allison, and W.F. Davidson. 1993. J. Immunol. 151:597.5. Gelfanov, V., Y.G. Lai, V. Gelfanova, J.Y. Dong, J.P. Su, and N.S. Liao. 1995. J. Immunol. 155:76.6. Harding, F.A., J.G. McArthur, J.A. Gross, D.H. Raulet, and J.P. Allison. 1992. Nature 356:607.7. Clements, J.L., G. Winslow, C. Donahue, S.M. Cooper, J.P. Allison, and R.C. Budd. 1993. Int. Immunol. 5:1451.8. Abe, R., P. Vandenberghe, N, Craighead, D.S. Smoot, K.P. Lee, and C.H. June. 1995. J. Immunol. 154:985.9. Levine, B.L., Y. Ueda, N. Craighead, M.L. Huang, and C.H. June. 1995. Int. Immunol. 7:891. |