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Antigenic Specificity | NCSTN |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Western blot analysis of brain cell and C6 cell lysate using NCSTN antibody. Nicastrin is a transmembrane glycoprotein serving as an essential component of the 3-secretase complex (1, 2). Nicastrin is physically associated with presenilin and plays an important role in the stabilization and correct localization of presenilin to the membrane-bound 3-secretase complex (3). Nicastrin also serves as a docking site for 3-secretase substrates such as APP and Notch, directly binding to them and properly presenting them to 3-secretase to ensure the correct cleavage process (2, 4). |
Immunogen | Immunogen: Recombinant protein of human NCSTN |
Other Names | n/a |
Gene, Accession # | [NCSTN] |
Catalog # | MBS419537 |
Price | $385 |
Order / More Info | NCSTN Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |