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Antigenic Specificity | Myelin Basic Protein |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a s |
Immunogen | Immunogen: A synthesized peptide derived from human Myelin Basic Protein. Subcellular Localization: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic side of myelin. Tissue Specificity: MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. |
Other Names | [Myelin basic protein; MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein; MBP], [MBP; MBP; MBP] |
Gene, Accession # | [MBP], Gene ID: 4155, NCBI: NP_001020252.1, UniProt: P02686 |
Catalog # | MBS179193 |
Price | $160, $340, $340 |
Order / More Info | Myelin Basic Protein Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |