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Antigenic Specificity | Mouse MAdCAM-1 |
Clone | [MAB0842] |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB); Neutralization. |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mucosal addressin cell adhesion molecule1 (MAdCAM1) is an immunoglobulin (Ig) cell adhesion molecule family member. In addition to Ig domains, it contains a mucin-like domain and a membrane proximal domain with similarity to IgA. MAdCAM1 is involved in lymphocyte homing to mucosal sites and is expressed on high endothelial venules (HEV) of both mesenteric lymph nodes and Peyer's patches. It has also been found to be expressed on sinuslining cells of the spleen. The integrin, alpha4beta7, has been shown to function as the MAdCAM1 receptor. The Ig domains of MAdCAM1 have been found to be critical to alpha4beta7 binding. The mucin domain has been shown to have activity in LSelectin binding. MAdCAM1 expression has been demonstrated to be upregu |
Immunogen | Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of MAdCAM-1 EC domain. |
Other Names | [Madcam1; AV211525], [Madcam1; Madcam1; AV211525] |
Gene, Accession # | [MAdCAM-1], Gene ID: 17123, NCBI: NP_038619.2, UniProt: G5E838 |
Catalog # | MBS690247 |
Price | $490 |
Order / More Info | Mouse MAdCAM-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |