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Antigenic Specificity | Ripk1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | peroxidase (HRP) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Pol |
Immunogen | Immunogen: Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1 protein (1-656AA) Conjugation: HRP |
Other Names | [Receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP; Receptor-interacting protein 1; RIP-1; Serine/threonine-protein kinase RIP; Ripk1; Rinp; Rip] |
Gene, Accession # | [Ripk1], Gene ID: 19766, NCBI: NP_033094.3, UniProt: Q60855 |
Catalog # | MBS7052906 |
Price | $160, $235 |
Order / More Info | Ripk1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |