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Antigenic Specificity | Human Complement Factor B/Bb |
Clone | [M13/12] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 k |
Format | fluorescein (FITC) conjugate |
Size | 0.1 mg |
Concentration | 0.1 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Complement Factor B/Bb. Anti-human complement factor B/Bb recognizes human complement factor B and its' cleavage product Bb. Complement factor B is a single-chain molecule of 764 amino acids (MW of 90 kDa) and is part of the alternative complement pathway. It is cleaved by Factor D yielding the non-catalytic Ba and the serine protease Bb. Bb associates with C3b and provides the catalytic subunit of the C5 convertase which cleaves C5 to C5a and C5b. Factor B is an acute-phase protein whose levels increase during inflammation. Additionally, Bb is involved in the proliferation and differentiation of pre-activated B-lymphocytes. Conversely, Ba has been shown to inhibit the proliferation of pre-activated B-lymphocytes. |
Immunogen | Hybridoma Production: Immunization: Immunization: Mouse monoclonal antibody raised against human complement factor B/Bb. Isotype Control: CLCMG101 |
Other Names | [Human Complement Factor B/Bb], [CFB; CFB; BF; FB; BFD; GBG; CFAB; CFBD; PBF2; AHUS4; FBI12; H2-Bf; ARMD14; BF; BFD; GBG] |
Gene, Accession # | Gene ID: 629, NCBI: NP_001701.2 |
Catalog # | MBS520699 |
Price | $305 |
Order / More Info | Human Complement Factor B/Bb Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Oppermann, M., Baumgarten, H., Brandt, E., Gottsleben, W., Kurts, C., and Gotze, O. (1990) J. Immunol. Methods 133, 181-1902.2. Oppermann, M., Kurts, C., Zierz, R., Quentin, E., Weber, M. H., and Gotze, O. (1991) Kidney Int. 40, 939- 947.3. Oppermann, M., Hopken, U., and Gotze, O. (1992) Immunopharm. 24, 119-134. |