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Antigenic Specificity | Plectin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, mouse |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | Size: 100 ug/200 ul |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes ~500 kDa of Plectin protein. It reacts with human, mouse and rat. The other species are not tested. Plectin is a cytoskeleton linker protein expressed in a variety of tissues including skin, muscle, and nerves. Plectin can bind to several molecules (intermediate filaments) that make up the cytoskeleton. Mutations in its gene are associated with epidermolysis bullosa simplex with late-onset muscular dystrophy. In certain skin cells, this protein is an essential part of hemidesmosomes, which attach the network of intermediate filaments to the cell membrane. It is also a component of desmosomes, which form junctions between neighboring cells. As part of these structures, plectin plays a critical role in anchoring the o |
Immunogen | Antigen Preparation: A synthetic peptide corresponding to the C-term portion of human Plectin. This sequence is identical to rat, mouse and human origins. |
Other Names | [Rabbit Plectin; Plectin; PLTN; PLEC1; intermediate filament binding protein 500kDa.], [PLEC; PLEC; HD1; PCN; EBS1; EBSO; PLTN; PLEC1; LGMD2Q; PLEC1b; PLEC1] |
Gene, Accession # | [Plectin], Gene ID: 5339, UniProt: Q15149 |
Catalog # | MBS462240 |
Price | $275 |
Order / More Info | Plectin Antibody from MYBIOSOURCE INC. |
Product Specific References | Johann W. Bauer et al. A Compound Heterozygous One Amino-Acid Insertion/Nonsense Mutation in the Plectin Gene Causes Epidermolysis Bullosa Simplex with Plectin Deficiency. Am J Pathol. 2001 February; 158 (2): 617-625. |