Edit |   |
---|---|
Antigenic Specificity | GRIN2A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626). Contributes to the slow phase of excitatory postsyna |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1130-1400 of human GRIN2A (NP 000824.1). |
Other Names | [LKS; EPND; FESD; NR2A; GluN2A; NMDAR2A] |
Gene, Accession # | [GRIN2A], Gene ID: 2903, NCBI: NP_000824.1, UniProt: Q12879 |
Catalog # | MBS8544130 |
Price | $280 |
Order / More Info | GRIN2A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |