Edit |   |
---|---|
Antigenic Specificity | Human TLR7 |
Clone | [4F4] |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | IgG concentration 1.0 mg/ml |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mouse anti Human TLR7, clone 4F4 recognizes human TLR7 (toll-like receptor 7), a 121 kDa type I transmembrane protein belonging to the toll-like receptor (TLR) family. TLR7is predominantly expressed in the spleen, lung and placenta (Chuang et al. 2000). TLRs are highly conserved proteins which play a key role in activation of innate immunity, through the recognition of distinct molecular patterns expressed by infectious agents. TLR7 recognizes and interacts with single-stranded RNA (ssRNA) derived from viruses such as influenza, HIV-1 (human immunodeficiency virus type I) and Sendai, and some siRNAs, resulting in the activation of the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway, and the production of proinflammat |
Immunogen | n/a |
Other Names | [toll-like receptor 7; Toll-like receptor 7; toll-like receptor 7; toll-like receptor 7-like; toll-like receptor 7], [TLR7; TLR7; TLR7-like] |
Gene, Accession # | [TLR7], Gene ID: 51284, NCBI: NP_057646.1, UniProt: Q9NYK1 |
Catalog # | MBS214463 |
Price | $495 |
Order / More Info | Human TLR7 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |