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Antigenic Specificity | Apoptosis-inducing factor 1 (AIF) (1B7) |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human, rat, monkey, Chinese hamster, dog |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: AIF (1B7) Mouse mAb detects endogenous levels of total AIF protein. A key event in the apoptotic process is the opening of the mitochondrial permeability transition pore, an event that is regulated by Bcl-2 family proteins, resulting in the release of several proteins from the mitochondrial intermembrane space. Several of these proteins participate in apoptosis, including cytochrome c, procaspases 2, 3, and 9 and AIF (apoptosis-inducing factor). AIF was shown to cause DNA fragmentation and chromatin condensation, and to induce the release of cytochrome c and caspase-9 from mitochondria. Bcl-2 overexpression was shown to prevent the release of AIF from mitochondria, but not to block its apoptogenic activity. |
Immunogen | Source Note: This monoclonal antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to residues within the carboxy terminus of AIF. |
Other Names | [apoptosis-inducing factor 1, mitochondrial isoform AIF; Apoptosis-inducing factor 1, mitochondrial; apoptosis-inducing factor 1, mitochondrial; apoptosis inducing factor mitochondria associated 1; Programmed cell death protein 8], [AIFM1; AIFM1; AIF; CMT2D; CMTX4; COWCK; DFNX5; NADMR; NAMSD; PDCD8; COXPD6; AIF; PDCD8] |
Gene, Accession # | [AIF], Gene ID: 9131, NCBI: NP_004199.1, UniProt: O95831 |
Catalog # | MBS435001 |
Price | $350, $565 |
Order / More Info | Apoptosis-inducing factor 1 (AIF) (1B7) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |