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Antigenic Specificity | Phospho-FoxO1 (Ser319) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB); Immunohistochemistry (IHC); ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Polyclonal antibody to detect FoxO1 (Phospho-Ser319) in human; mouse and Rat samples. Forkhead box O (FoxO) transcription factors are downstream targets of the serine/threonine protein kinase B (PKB) /Akt. The Akt kinase regulates processes of cellular proliferation and survival. Within the family; three members (FoxO1; FoxO4; and FoxO3a) have sequence similarity to the nematode orthologue DAF-16; which mediates signaling via a pathway involving IGFR1; PI3K; and Akt. The FoxO signaling is regulated by their interactions with other intracellular proteins as well as their post-translational modifications such as phosphorylation. Increased proliferation results when forkhead transcription factors are inactivated through phosphorylation by Akt |
Immunogen | Immunogen: Synthesized peptide derived from human FoxO1 around the phosphorylation site of S319 |
Other Names | [FOXO1; FKHR; FOXO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma], [FOXO1; FOXO1; FKH1; FKHR; FOXO1A; FKHR; FOXO1A] |
Gene, Accession # | [FoxO1], Gene ID: 2308, NCBI: NP_002006.2, UniProt: Q12778 |
Catalog # | MBS845896 |
Price | $335 |
Order / More Info | Phospho-FoxO1 (Ser319) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |