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Antigenic Specificity | BID |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total BID protein. The BH3 domain-only protein, BID, a death agonist member of the Bcl-2/Bcl-xL family (1), is localized in the cytosolic fraction of cells as an inactive precursor (2,3). Its active form is generated upon proteolytic cleavage by caspase-8 in the Fas signaling pathway. Cleaved BID translocates to mitochondria and induces cytochrome c release and mitochondrial damage (2-5). Thus, BID relays an apoptotic signal from the cell surface to mitochondria. However, the precise molecular mechanism for the translocation of the cleaved BID, and for the subsequent release of cytochrome c during apoptosis, is still unclear. |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human BID. |
Other Names | [BID; FP497; MGC15319; MGC42355] |
Gene, Accession # | [BID], Gene ID: 637, NCBI: NP_001187.1, UniProt: P55957 |
Catalog # | MBS9403310 |
Price | $255 |
Order / More Info | BID Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |