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Antigenic Specificity | CHP2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CHP2 antibody detects endogenous levels of total CHP2. Function: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.Subunit Structure: Interacts with PPP3CA. Interacts with SLC9A1/NHE1; the interaction occurs in a calcium- |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Plasma Membrane; Nucleus Tissue Specificity: Expressed in malignantly transformed cells but not detected in normal tissues. Predicted Cross Reactivity: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit Similarity: Pig (100%), Zebrafish (80%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%) |
Other Names | [Calcineurin B homologous protein 2; HCA520; Hepatocellular carcinoma associated antigen 520] |
Gene, Accession # | [CHP2], Gene ID: 63928, NCBI: NP_071380.1, UniProt: O43745 |
Catalog # | MBS9605316 |
Price | $240, $280 |
Order / More Info | CHP2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |