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Antigenic Specificity | Mouse Dual specificity mitogen-activated protein kinase kinase 4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | biotin conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite f |
Immunogen | Immunogen: Recombinant mouse Dual specificity mitogen-activated protein kinase kinase 4 protein(2-397a) |
Other Names | [C-JUN N-terminal kinase kinase 1; JNK-activating kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; Jnkk1; Mek4; Prkmk4; Sek1; Serk1; Skk1; Map2k4], [Map2k4; Map2k4; MEK4; MKK4; Sek1; JNKK1; Serk1; PRKMK4; Jnkk1; Mek4; Mkk4; Prkmk4; Sek1; Serk1; Skk1; MAP kinase kinase 4; MAPKK 4; JNK kinase 1; JNKK 1; MEK 4; SEK1] |
Gene, Accession # | [Mkk4], Gene ID: 26398, NCBI: NP_033183.1, UniProt: P47809 |
Catalog # | MBS1493211 |
Price | $160, $235 |
Order / More Info | Mouse Dual specificity mitogen-activated protein kinase kinase 4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |