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Antigenic Specificity | RIP3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 0.5 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: Receptor interacting protein including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the c-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, and mediates TNF-R1 mediated apoptosis, and attenuates RIP and TNFR1 induced NFkB activation. Overexpression of RIP3 induces apoptosis and NFkB activation. |
Immunogen | Immunogen: Synthetic peptide corresponding to residues surrounding amino acid 476 of mouse RIP3 |
Other Names | [RIP like protein kinase 3; RIPK3; RIPK3], [Ripk3; Ripk3; Rip3; AW107945; 2610528K09Rik; Rip3; RIP-3; mRIP3] |
Gene, Accession # | [RIP3], Gene ID: 56532, NCBI: NP_001157580 |
Catalog # | MBS840844 |
Price | $330 |
Order / More Info | RIP3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |