Edit |   |
---|---|
Antigenic Specificity | Phospho-ITGB3-Y773 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Integrin a-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin a-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins a-IIb/beta-3 and a-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin a-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin a-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV |
Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding Y773 of human ITGB3 Calculated Molecular Weight: 110kDa |
Other Names | [Phospho-ITGB3-Y773: CD61 antigen; GP3A; GPIIIa; ITB3; Platelet membrane glycoprotein IIIa], [ITGB3; ITGB3; GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16; GP3A; GPIIIa] |
Gene, Accession # | [ITGB3], Gene ID: 3690, NCBI: P05106.2, UniProt: P05106 |
Catalog # | MBS128293 |
Price | $235, $350, $525 |
Order / More Info | Phospho-ITGB3-Y773 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |