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Antigenic Specificity | BAK (N-TERMINAL) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | IgG concentration 1.0mg/ml |
Applications | Immunohistology Frozen, Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti BAK (N-Terminal) antibody recognizes the Bcl-2 homologous antagonist/killer (Bak), an oligomeric protein localised to the outer mitochondrial membrane and the endoplasmic reticulum of healthy cells. Bak is a pro-apoptotic Bcl-2 family member similar to Bax with which it is thought to share significant homology. Mcl-1 and Bcl-xL interact with Bak and prevent the activation of Bak in healthy cells. Upon cytotoxic signalling, Mcl-1- and Bcl-xL-binding proteins (such as Noxa and Bad) displace Bak and apoptosis is induced. When activated, Bak (and Bax) permeabilises the outer membrane of the mitochondria or the ER to release proapoptogenic factors such as cytochrome c. |
Immunogen | Immunogen: A peptide corresponding to 13 amino acids near the amino terminus of human BAK. Buffer Solution: Phosphate buffered saline Antiserum Preparation: Antiserum to BAK (NT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography. Target Species: Human |
Other Names | [Bcl-2 homologous antagonist/killer; Bcl-2 homologous antagonist/killer; bcl-2 homologous antagonist/killer; Bcl2 homologous antagonist/killer; apoptosis regulator BAK; BCL2-antagonist/killer 1; Apoptosis regulator BAK], [Bak1; Bak1; Bak; N-Bak; N-BAK1; Bak] |
Gene, Accession # | [BAK], Gene ID: 12018, NCBI: O08734.2 |
Catalog # | MBS224014 |
Price | $375 |
Order / More Info | BAK (N-TERMINAL) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |