LFA3 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityLFA3
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman.
Isotypen/a
Formatimmunogen affinity purified
Size0.1 mg
Concentrationn/a
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC) Paraffin
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DescriptionRabbit IgG polyclonal antibody for Lymphocyte function-associated antigen 3 (CD58) detection. Background: CD58, or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages. It binds to CD2 (LFA-2) on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell activation, when T cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T-cell receptors are reactive to. The LFA3 gene is mapped to chromosome 1p13, which is the same locati
ImmunogenImmunogen: E Coli-derived human LFA3 recombinant protein (Position: F29-R215).
Other Names[AG3; CD58; CD58 antigen; CD58 molecule; LFA 3; LFA-3; LFA3; P19256; Lymphocyte function-associated antigen 3; CD58 molecule], [CD58; CD58; ag3; LFA3; LFA-3; LFA3; Ag3]
Gene, Accession #[CD58], Gene ID: 965, NCBI: NP_001138294.1, UniProt: P19256
Catalog #MBS178408
Price$315
Order / More InfoLFA3 Antibody from MYBIOSOURCE INC.
Product Specific References1. Barbosa, J. A., Mentzer, S. J., Kamarck, M. E., Hart, J., Biro, P. A., Strominger, J. L., Burakoff, S. J. Gene mapping and somatic cell hybrid analysis of the role of human lymphocyte function-associated antigen-3 (LFA-3) in CTL-target cell interactions. J. Immun. 136: 3085-3091, 1986. 2. Sewell, W. A., Palmer, R. W., Spurr, N. K., Sheer, D., Brown, M. H., Bell, Y., Crumpton, M. J. The human LFA-3 gene is located at the same chromosome band as the gene for its receptor CD2. Immunogenetics 28: 278-282, 1988. 3. Wang, J., Smolyar, A., Tan, K., Liu, J., Kim, M., Sun, Z. J., Wagner, G., Reinherz, E. L. Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors. Cell 97: 791-803, 1999.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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