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Antigenic Specificity | Human Siglec-3 |
Clone | [5C24] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Siglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: siglecs-1, -2, and -4, and a siglec-3/CD33-related subgroup (siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides f |
Immunogen | Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with the extracellular domain of recombinant human Siglec-3, also called CD33. |
Other Names | [CD33; p67; SIGLEC3; SIGLEC-3], [CD33; CD33; p67; SIGLEC3; SIGLEC-3; SIGLEC3; Siglec-3] |
Gene, Accession # | [Siglec-3], Gene ID: 945, NCBI: NP_001076087.1, UniProt: P20138 |
Catalog # | MBS690982 |
Price | $490 |
Order / More Info | Human Siglec-3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |