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Antigenic Specificity | Phospho-MEK1 (S222) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: Drosophila, hamster, mouse, rabbit, rat, Xenopus, chicken) |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Dot Blot (DB), ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MEK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S222 of human MEK1. MEK1is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax. |
Immunogen | n/a |
Other Names | [Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; MAP2K1; MEK1; PRKMK1] |
Gene, Accession # | [MAP2K1], Gene ID: 5604, NCBI: NP_002746.1, UniProt: Q02750 |
Catalog # | MBS9214735 |
Price | $165, $370 |
Order / More Info | Phospho-MEK1 (S222) Antibody from MYBIOSOURCE INC. |
Product Specific References | Ohren, J.F., et al., J. Neural Transm. 11(12):1192-1197 (2004). Naegele, S., et al., J. Biol. Chem. 279(44):46023-46034 (2004). Ussar, S., et al., J. Biol. Chem. 279(42):43861-43869 (2004). Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004). Spence, H.J., et al., EMBO Rep. 5(5):484-489 (2004). |