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Antigenic Specificity | Human Integrin alpha-IIb |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | caprylic acid ammonium sulfate precipitate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
Immunogen | Immunogen: Recombinant human Integrin alpha-IIb protein(639-887AA) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6602 / sc-6604 / sc-15328 |
Other Names | [GPalpha IIb; Platelet membrane glycoprotein IIb; CD41; GP2B; ITGAB; ITGA2B], [ITGA2B; ITGA2B; GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93; GP2B; ITGAB; GPIIb] |
Gene, Accession # | Gene ID: 3674, NCBI: NP_000410.2, UniProt: P08514 |
Catalog # | MBS1493980 |
Price | $160, $235 |
Order / More Info | Human Integrin alpha-IIb Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |