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Antigenic Specificity | p38 alpha MAP Kinase (C-terminal) |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human, rat, mouse |
Isotype | IgG1 |
Format | Protein A purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA, Western Blot, Immunocytochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody detects a 42 kDa* protein corresponding to the apparent molecular mass of p38-alpha on SDS-PAGE immunoblots of human Jurkat, A431, and HeLa cells. p38 MAP kinase (MAPK), also called RK, CSBP, and SAPK2a, is the mammalian orthologue of the yeast HOG kinase. This family of kinases participates in signaling cascades that control cellular responses to cytokines and stress. Four isoforms of p38 MAPK (alpha, beta, gamma, delta) have been identified. Similar to the SAPK/JNK pathway, p38 MAPK is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides, UV light and growth factors. MKK3 and SEK activate p38 MAPK by dual phosphorylation at threonine 180 and tyrosine 182. Activated |
Immunogen | Immunogen: Clone M138 was generated from a recombinant protein corresponding to amino acid residues in the C-terminal region of rat p38-alpha. This sequence is identical in human and mouse p38-alpha. |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS470021 |
Price | $325 |
Order / More Info | p38 alpha MAP Kinase (C-terminal) Antibody from MYBIOSOURCE INC. |
Product Specific References | • Han, J. et al. (1994) Science 265, 808-811.• Lee, J. C. et al. (1994) Nature 372, 739-746.• Rouse, J. et al. (1994) Cell 78, 1027-1037.• Freshney, N. W. et al. (1994) Cell 78, 1039-1049.• Raingeaud, J. et al. (1995) J. Biol. Chem. 270, 7420-7426. |