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Antigenic Specificity | Human CD261 |
Clone | [DR-4-02] |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.025 mg |
Concentration | IgG concentration 1.0 mg/ml |
Applications | Flow cytometry (FC/FACS), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mouse anti Human CD261 antibody, clone DR-4-02 recognizes human death receptor 4 (DR4), also known as CD261 or TRAIL- R1. DR4 is a type I transmembrane protein of 468 amino acids, which is expressed in most human tissues including spleen, peripheral blood leucocytes, thymus and in a variety of tumour-derived cell lines. DR4 plays a role in inducing cell death. The binding of TRAIL to DR4 triggers the activation of pro-caspases 8 and 10, leading to apoptosis. |
Immunogen | Immunogen: Fusion protein containing the extracellular region of CD261 (DR4). Fusion Partners: Spleen cells from immunised F1 hybrid mice were fused with cells of the SP2/0-Ag14 myeloma cell line. Buffer Solution: Phosphate buffered saline Target Species: Human |
Other Names | [tumor necrosis factor receptor superfamily member 10A; Tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10A; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; cytotoxic TRAIL receptor; death receptor 4; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a; Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; CD_antigen: CD261], [TNFRSF10A; TNFRSF10A; DR4; APO2; CD261; TRAILR1; TRAILR-1; APO2; DR4; TRAILR1; TRAIL receptor 1; TRAIL-R1] |
Gene, Accession # | [CD261], Gene ID: 8797, NCBI: NP_003835.3, UniProt: O00220 |
Catalog # | MBS215943 |
Price | $175 |
Order / More Info | Human CD261 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |