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Antigenic Specificity | Androgen Receptor |
Clone | polyclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 3 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Formalin/Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody to androgen receptors binds to these proteins in nuclei of typical normal tissues. Over-expression may be observed in tumours like prostate carcinoma and osteosarcoma. For information transmission to the target cells male steroid hormones like Testosterone and DHT require a specific receptor. This specific receptor, called androgen receptor, is found in numerous human tissues like skin, mucous membranes, seminal vesicles, prostate gland and testis. Androgen receptors will also be found in human tumours like prostate carcinoma, osteosarcoma and others. In prostate carcinoma the clinical relevance has been proven by castration and androgen deprivation by Gn-RH-agonist and -antagonist treatment. In many cases androgen deprivation |
Immunogen | Immunogen: Synthetic peptide |
Other Names | [Androgen receptor; Androgen receptor; Androgen receptor], [androgen receptor] |
Gene, Accession # | NCBI: Q91426, UniProt: Q91426 |
Catalog # | MBS396991 |
Price | $380 |
Order / More Info | Androgen Receptor Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Veldscholte J., Berrevoets C.A., Zegers N.D., van der Kwast T.H., Grootegoed J.A., and Mulder E. (1992) Hormone -induced dissociation of the androgen receptor-heat-shock-protein complex: use of a new monoclonal antibody to distinguish transformed from nontransformed receptors. Biochem. 31(32);7422-7430. 2. Iwamura M., Abrahamsson P.A., Benning C.M., Cockett A.T., di Sant'Agnese P.A. (1994) Androgen receptor immunostaining and its tissue distribution in formalin-fixed paraffin-embedded sections after microwave treatment. J. Histochem. Cytochem. 42(6); 783-788. 3. Shikata N., Kurokawa I., Andachi H., Tsubura A. (1995) Expression of androgen receptors in skin appendage tumors: an immunohistochemical study. J. Cutan. Pathol. 22(2); 149-153. 4. Magi-Galluzzi C., Montironi R., Prete E., Kwan P.W., and Delellis R.A. (1996) Effect of microwave oven heating times on androgen receptor antigen retrieval from paraffin-embedded prostatic adenocarcinoma. Anticancer Res. 16(5A9; 2931-2936. 5. Kim D., Gregory C.W., Smith G.J., Mohler J.L. (1999) Immunhistochemical quantitation of androgen receptor expression using color video image analysis. Cytometry 35(1); 2-10. |