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Antigenic Specificity | Aak1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | AP2-associated protein kinase 1 (Aak1) is a member of the Ark1/Prk1 subfamily of Ser/Thr protein kinases that are thought to regulate endocytosis by phosphorylating the accessory endocytic components. Aak1 interacts with and phosphorylates the mu2 subunit of the AP-2 complex, which promotes binding of the AP-2 to tyrosine based (Yxxphi) internalization motif-containing receptors and subsequent receptor endocytosis. At least two isoforms of Aak1 are known to exist; the longer isoform contains an extended carboxy-terminus that contains an additional clathrin-binding domain. Overexpression of this long isoform or Aak1 depletion by RNA interference impairs transferrin recycling from the early/sorting endosome, suggesting that Aak1 functions at |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 20 amino acid peptide near the amino terminus of the human Aak1. |
Other Names | [AP2-associated protein kinase 1] |
Gene, Accession # | [Aak1], Gene ID: 22848, NCBI: NP_055726 |
Catalog # | MBS9407929 |
Price | $320 |
Order / More Info | Aak1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |