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Antigenic Specificity | TOK-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: TOK-1 Polyclonal Antibody detects endogenous levels of TOK-1 protein. BCCIP (BRCA2 and CDKN1A interacting protein) product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle p |
Immunogen | Immunogen: Synthesized peptide derived from the internal region of human TOK-1 at AA range: 60-140 |
Other Names | [Rabbit TOK-1; BCCIP; TOK1; BRCA2 and CDKN1A-interacting protein; P21-and CDK-associated protein 1; Protein TOK-1] |
Gene, Accession # | [TOK-1], Gene ID: 56647, NCBI: NP_510868, UniProt: Q9P287 |
Catalog # | MBS9706481 |
Price | $130, $220, $325 |
Order / More Info | TOK-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |