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Antigenic Specificity | PP4R2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total PP4R2 protein. Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human PP4R2. |
Other Names | [MGC131930; PP4R2; protein phosphatase 4; regulatory subunit 2] |
Gene, Accession # | [PP4R2], Gene ID: 151987, NCBI: NP_777567.1, UniProt: Q9NY27 |
Catalog # | MBS9407974 |
Price | $200, $255 |
Order / More Info | PP4R2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |