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Antigenic Specificity | RUSC1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with IkB kinase- (IKK-) gamma, the regulatory subunit of the IKK complex that is required for NF-kB activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-m |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 17 amino acid peptide from near the carboxy terminus of human RUSC1. |
Other Names | [RUN and SH3 domain containing protein 1, NESCA] |
Gene, Accession # | [RUSC1], Gene ID: 23623, NCBI: NP_001098673 |
Catalog # | MBS9403125 |
Price | $320 |
Order / More Info | RUSC1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |