Edit |   |
---|---|
Antigenic Specificity | SCF |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total SCF protein. Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promo |
Immunogen | Immunogen: Peptide sequence around aa.265~269(E-K-E-R-E) derived from Human SCF. |
Other Names | [SF; MGF; FPH2; KL-1; Kitl] |
Gene, Accession # | [SCF], Gene ID: 4254, NCBI: NP_000890.1, UniProt: P21583 |
Catalog # | MBS8511718 |
Price | $290 |
Order / More Info | SCF Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |