Edit |   |
---|---|
Antigenic Specificity | OSBPL3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:174 |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 370-520 of human OSBPL3 (NP 056365.1). |
Other Names | [ORP3; ORP-3; OSBP3] |
Gene, Accession # | [OSBPL3], Gene ID: 26031, NCBI: Q9H4L5.1, UniProt: Q9H4L5 |
Catalog # | MBS8545413 |
Price | $280 |
Order / More Info | OSBPL3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |