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Antigenic Specificity | Trk A (Phospho-Tyr757) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of Trk A only when phosphorylated at tyrosine 757. Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.Martin-Zanca D., Mol. Cell. Biol. 9:24-33(1989).Shelton D.L., J. Neurosci. 15:477-491(1995).The MGC Project Team, Genome Res. 14:2121-2127(2004). |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of tyrosine 757 (E-V-Y(p)-A-I) derived from Human Trk A. |
Other Names | [TRKA; TRK; NTRK1; p140-TrkA] |
Gene, Accession # | [Trk A], Gene ID: 4914, NCBI: NP_001007793.1, UniProt: P04629 |
Catalog # | MBS9403981 |
Price | $200, $255 |
Order / More Info | Trk A (Phospho-Tyr757) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |