PKM1/2 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-PKM1/2 antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | PKM1/2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to Human PKM1/2. Pyruvate kinase, a glycolytic enzyme, catalyses the conversion of phosphoenolpyruvate to pyruvate. In mammals, the M1 isoform (PKM1) is expressed in most adult tissues (1). The M2 isoform (PKM2), an alternatively-spliced variant of M1, is expressed during embryonic development (1). Studies found that cancer cells exclusively express PKM2 (1-3). PKM2 is shown to be essential for aerobic glycolysis in tumors (Warburg effect) (1). When the M2 isoform is switched to the M1 isoform, aerobic glycolysis is reduced and oxidative phosphorylation is increased in cancer cells (1). These cells also show decreased tumorigenicity in mouse xenografts (1). Recent studies show that the oncogenic forms of FGFR1 directly pho |
| Immunogen | Immunogen: A synthetic -peptide of human PKM1/2 |
| Other Names | [PKM2; PKM1/2; PKM1/2; PKM2; PK3; PKM; TCB; OIP3; CTHBP; THBP1;], [PKM; PKM; PK3; TCB; OIP3; PKM2; CTHBP; THBP1; OIP3; PK2; PK3; PKM2; CTHBP; OIP-3; THBP1] |
| Gene, Accession # | Gene ID: 5315, NCBI: NP_001193725.1, UniProt: P14618 |
| Catalog # | MBS125196 |
| Price | $235, $350, $525 |
| Order / More Info | PKM1/2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Christofk, H.R. et al. (2008) Nature 452, 230-3. 2. Mazurek, S. et al. (2005) Semin Cancer Biol 15, 300-8. 3. Dombrauckas, J.D. et al. (2005) Biochemistry 44, 9417-29. 4. Hitosugi, T. et al. (2009) Sci Signal 2, ra73. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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