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Antigenic Specificity | Fibrillarin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Fibrillarin is a 2'-O-methyltransferase located in fibrillar regions and Cajal bodies of the nucleolus, where RNA transcription and pre-RNA processing take place. Fibrillarin associates with several other structual proteins as well as box C/D snoRNA to form a complex that functions in pre-rRNA processing, pre-rRNA methylation and ribosome assembly. This complex catalyzes site-specific 2'-O-ribose methylation of targeted nucleotides within the rRNA sequence. The sequence, structure and function of fibrillarin are highly conserved and fibrillarin gene expression is essential for early embryonic development. |
Immunogen | Immunogen: A synthesized peptide derived from human Fibrillarin |
Other Names | [fibrillarin; rRNA 2'-O-methyltransferase fibrillarin; rRNA 2'-O-methyltransferase fibrillarin; fibrillarin; 34 kDa nucleolar scleroderma antigen] |
Gene, Accession # | [FBL], Gene ID: 2091, NCBI: CAA39935.1, UniProt: P22087 |
Catalog # | MBS8542537 |
Price | $280 |
Order / More Info | Fibrillarin Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |