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Antigenic Specificity | Paxillin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.05 mg |
Concentration | 1 mg/ml |
Applications | Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Paxillin is a signal transduction adaptor protein discovered in 1990 in the laboratory of Keith Burridge and should not be confused with the neurotoxin paxilline. The C-terminal region of paxillin contains four LIM domains that target paxillin to focal adhesions, it is presumed through a direct association with the cytoplasmic tail of beta-integrin. The N-terminal region of paxillin is rich in protein protein interaction sites. The proteins that bind to paxillin are diverse and include protein tyrosine kinases, such as Src and FAK, structural proteins, such as vinculin and actopaxin, and regulators of actin organization, such as COOL/PIX and PKL/GIT. |
Immunogen | Immunogen: Paxillin antibody was raised in Rabbit using the peptide sequence around phosphorylation site of tyrosine 118 (H-V-Y(p)-S-F) derived from Human Paxillin as the immunogen. |
Other Names | [Rabbit Paxillin; Paxillin; Paxillin; Phospho Tyr118; PXN] |
Gene, Accession # | [PXN], Gene ID: 395832, NCBI: NP_990315.1, UniProt: P49024 |
Catalog # | MBS5309508 |
Price | $295 |
Order / More Info | Paxillin Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |