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Antigenic Specificity | Human CD86 |
Clone | [4ABU63] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 50 tests, 100 tests |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD86 also known as B7-2, is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors.It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86, along with CD80/B7-1.is an important accessory molecule in T cell costimulation via it's interaciton with CD28 and CD152/CTLA4.Since CD86 has rapid kinetics of induction.it is believed to be the major CD28 ligand expressed early in the immune response.it is also found on malignant Hodgkin and Reed Sternberg(HRS) cells in Hodgkin's disease. |
Immunogen | n/a |
Other Names | [CD86, partial; T-lymphocyte activation antigen CD86; T-lymphocyte activation antigen CD86; CD86 molecule; Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD_antigen: CD86] |
Gene, Accession # | [CD86], Gene ID: 942, NCBI: CAG46642.1, UniProt: P42081 |
Catalog # | MBS8501761 |
Price | $280, $300 |
Order / More Info | Human CD86 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Knapp, W et al., eds. (1989) Leucocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, New York. 2. Lanier LL. et al. (1991) J. Immunol. 146:4421-4426. 3. Campbell, JJ et al. (2001) J. Immunol. 166:6477-6482. 4. Cooper MD et al. (2001) Trends in Immunol. 22:633-640. 5. Galandrini R et al. (2002) Blood. 100:4581-4589. |