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Antigenic Specificity | MEK Kinase-3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: MEK Kinase-3 Polyclonal Antibody detects endogenous levels of MEK Kinase-3 protein. MAP3K3 product is a 626-amino acid polypeptide that is 96% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4. -kb transcript that appears to be ubiquitously expressed. Mitogen-activated protein kinase kinase kinase 3 directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB) |
Immunogen | Immunogen: Synthesized peptide derived from the internal region of human MEK Kinase-3 at AA range: 70-150 |
Other Names | [Rabbit MEK Kinase-3; MAP3K3; MAPKKK3; Mitogen-activated protein kinase kinase kinase 3; MAPK/ERK kinase kinase 3; MEK kinase 3; MEKK 3] |
Gene, Accession # | [MEKK3], Gene ID: 4215, NCBI: NP_002392.2, UniProt: Q99759 |
Catalog # | MBS9702463 |
Price | $130, $220, $325 |
Order / More Info | MEK Kinase-3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |