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Antigenic Specificity | ZC3HC1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. |
Immunogen | Immunogen: Recombinant human Nuclear-interacting partner of ALK protein (N-260AA) |
Other Names | [Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; hNIPA; Zinc finger C3HC-type protein 1; ZC3HC1; NIPA; HSPC216] |
Gene, Accession # | [ZC3HC1], Gene ID: 51530, NCBI: NP_001269119.1, UniProt: Q86WB0 |
Catalog # | MBS7045664 |
Price | $120, $160 |
Order / More Info | ZC3HC1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |