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Antigenic Specificity | KDM1A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono-(H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to AND |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 130-380 of human KDM1A (NP 055828.2). |
Other Names | [AOF2; CPRF; KDM1; LSD1; BHC110] |
Gene, Accession # | [KDM1A], Gene ID: 23028, NCBI: NP_001009999.1, UniProt: O60341 |
Catalog # | MBS8550079 |
Price | $280 |
Order / More Info | KDM1A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |