Edit |   |
---|---|
Antigenic Specificity | YEAST RAD9 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 0.05 mg |
Concentration | IgG concentration 0.5mg/ml |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This item detects Saccharomyces cerevisiae Rad9, a protein involved in the DNA damage checkpoint. In S. cerevisiae this checkpoint is mainly controlled by the PI(3) kinase-like kinase (PIKK) Mec1, which is activated in response to DNA damage. Activated Mec1 hyperphosphorylates Rad9, which in turn triggers the binding of Rad53, the orthologue of mammalian Chk2. Activated Rad53 specifically targets substrates required for cell cycle arrest, gene expression and efficient DNA repair. Mutations affecting Rad9 impair checkpoint induced cell-cycle arrest and increase genomic instability.. . This antibody is pan reactive with both the phosphorylated and non-phosphorylated forms of this protein. MBS222775 detects Saccharomyces cerevisiae Rad9, a p |
Immunogen | Immunogen: Synthetic peptide corresponding to aa 1125-1139 of yeast Rad9 protein conjugated to Keyhole Limpet Haemocyanin (KLH). Buffer Solution: Phosphate buffered saline Antiserum Preparation: Antisera to yeast Rad9 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. Target Species: Yeast |
Other Names | [chromatin-binding protein RAD9; DNA repair protein RAD9; chromatin-binding protein RAD9], [RAD9; RAD9] |
Gene, Accession # | Gene ID: 851803, NCBI: NP_010503.1, UniProt: P14737 |
Catalog # | MBS222775 |
Price | $375 |
Order / More Info | YEAST RAD9 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |