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Antigenic Specificity | Pro-Survival Bcl-2 Family Antibody Sampler Kit |
Clone | n/a |
Host Species | n/a |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 1 kit |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: The Bcl-2 family consists of a number of evolutionarily conserved proteins containing Bcl-2 homology domains (BH) that regulate apoptosis through control of mitochondrial membrane permeability and release of cytochrome c. Four BH domains have been identified (BH1-4) that mediate protein interactions. The family can be separated into three groups based upon function and sequence homology: pro-survival members include Bcl-2, Bcl-xL, Mcl-1, A1 and Bcl-w; pro-apoptotic proteins include Bax, Bak and Bok; and BH3 only proteins Bad, Bik, Bid, Puma, Bim, Bmf, Noxa and Hrk. Interactions between death- promoting and death-suppressing Bcl-2 family members has led to a rheostat model in which the ratio of pro-apoptotic and anti-apoptotic |
Immunogen | n/a |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS2550096 |
Price | $345 |
Order / More Info | Pro-Survival Bcl-2 Family Antibody Sampler Kit Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |