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Antigenic Specificity | TrkA (Ab-791) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total TrkA protein. Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around aa.789~793 (P-V-Y-L-D) derived from Human TrkA. |
Other Names | [High affinity nerve growth factor receptor precursor; NTRK1; Slow nerve growth factor receptor; TRK; TRK1 transforming tyrosine kinase protein] |
Gene, Accession # | [TrkA], Gene ID: 4914, NCBI: NP_001007793.1, UniProt: P04629 |
Catalog # | MBS9400735 |
Price | $200, $255 |
Order / More Info | TrkA (Ab-791) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |