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Antigenic Specificity | CD123, IL-3Ra |
Clone | [CD123-D3] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1/k |
Format | unconjugated |
Size | 5 Control Slides, 0.1 mL (Concentrate), 3 ml (Prediluted) |
Concentration | n/a |
Applications | n/a |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD123 is alpha chain of the IL-3 receptor. This 60-70 kDa transmembrane protein, by itself, binds to IL-3 with rather low affinity. However, when associated with CD131 (common beta chain), the protein binds to IL-3 with high affinity. The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes. The receptor belongs to the Type I cytokine-receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CDw131) subunit. The CD123 receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines. CD123 is expressed by myeloid precursors, macrophages, den |
Immunogen | n/a |
Other Names | n/a |
Gene, Accession # | [CD123] |
Catalog # | MBS370017 |
Price | $130, $195, $225 |
Order / More Info | CD123, IL-3Ra Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |